Product Evidence

Loved by the Earth and Hundreds of Clients

Vivolor¬ģ¬†Memory Support’s ingredients are naturally grown and proven to be helpful, sustainable and¬†Generally Regarded As Safe (GRAS) by the FDA.¬† Below is science-based evidence supporting each ingredient’s ability to improve memory and cognition plus provide mega-nutrients to the brain.¬†Vivolor products have not been evaluated for their effectiveness in treating the health conditions described herein.


Bacopa is an Indian herb used for centuries that enhances memory1,2,3,4,5,6,7, protects nerves1,3,4,6,8, reduces inflammation1,6,7, improves intelligence3,4, reduces oxidation1,6,8, relieves pain1,7, improves learning2,4,5, prevents cognitive deficits1,3,4,6, increases brain blood flow6, increases energy metabolism6, improves information processing speed1,6, reduces beta amyloid plaques1,8, increases acetylcholine4,8, and improves brain function6,8.  There are numerous studies of bacopa in labs, animals, and humans.  289 human studies were identified, of which 9 studies were randomized, placebo-controlled human trials (the highest level of evidence) of chronic use (12 or more weeks of treatment) of bacopa including 518 subjects1. These studies showed that bacopa monnieri has the potential to improve cognitive performance and decrease choice reaction time (a measure of speed and attention). 1 In cultured neurons, bacopa protected neurons from beta-amyloid induced cell death, suppressed acetylcholinesterase, and promoted cell survival. 5

The charts display the results of a double-blind, placebo-controlled study of bacopa in 46 healthy volunteers age 18-60 after 12 weeks of dosing at Swinburne University9.  Results of the AVLT (Auditory Verbal Learning Test) indicated statically significantly improved speed of information processing, improved learning, improved memory (decreased forgetting and decreased proactive interference), reduced inspection time, and reduced anxiety. 9

Curcumin (from turmeric root)

Curcumin is an amazing herbal supplement that provides numerous health benefits.  Curcumin is a potent anti-oxidant10,11,12,14,15,16,18, anti-inflammatory10,11,14,15,18, enhances cognition10,11,12,13,14.16, prevents neurodegeneration10,11,15, reduces beta amyloid plaques10,11,17,18, improves attention11, increases alertness11, enhances memory11,13, improves mood11,13,15, improves lipids and cholesterol11, improves mitochondrial function12, enhances neuron function12, promotes neurogenesis and neural plasticity11, beneficially influences neurotransmitters11, increases neurotrophic factor and signaling kinases13,14, reduces mental fatigue11,16, increases calmness11,16, and showed 50% reduction in beta amyloid plaques17.  The Achilles heel of native curcumin is that absorption into the body is typically less than 1%.  That means if you take 100mg, less than 1mg gets into your body!  Glory DayTM Brain Booster has a novel, patent protected method of dramatically enhancing absorption over 185 times in comparison to native curcumin so that you can benefit from curcumin’s excellent health promoting properties!

The charts show results of a randomized, double-blind, placebo-controlled study of curcumin with enhanced bioavailability in 61 healthy individuals age 60-85.  Digit Vigilance Tests measure sustained attention and psychomotor speed and involve finding and crossing out sixes or nines which appear randomly within 59 rows of single digits in a 10 minute timed test.

Curcumin statistically significantly improved accuracy, improved math (subtraction), increased calmness, enhanced contentedness and reduced fatigue11.  Lipids were significantly improved (reduced cholesterol and reduced low density lipoproteins (LDL)) with chronic use of curcumin.11

DHA (docosahexaenoic acid from omega 3 fish oil)

Your brain is 60% fat and DHA is the largest component of that fat which is naturally occurring in human brains.  DHA is the most important and powerful natural fat in our brain and decreases with age after 20 years of age19.  Your body cannot make DHA, so it is critical to consume DHA in a supplement.  DHA in the brain is greatly decreased in Alzheimer’s disease19.  In longitudinal studies, increased levels of DHA correlated with decreased cognitive decline19.  In numerous studies, consistent DHA taken long-term reduced beta amyloid deposits, reduced loss of hippocampal neurons and improved cognitive function in rats19.  DHA has also been correlated with higher brain volume (less shrinking of the brain which is typical of dementia) in humans19.  CDC recommends 2-3 fish meals per week or the equivalent intake of fatty acids, particularly DHA19.  In the Framingham Study, decreased DHA was related to subsequent cognitive decline19,20.  The top quartile with the highest plasma DHA had statistically significant 47% reduction in the risk of developing dementia from any cause after 9 years of follow up19,20.  A dose-response relationship was observed between DHA serum levels and cognitive performance scores23,85.  Higher DHA levels were associated with better scores on non-verbal reasoning, mental flexibility, working memory and vocabulary23,85.    DHA improves visual memory, abstract skills, immediate recall, short term memory, working memory19,20,23, verbal memory, semantic memory function21, delayed recall, non-verbal reasoning23, mental flexibility23, vocabulary23, attention, speed and executive function19,20.   Favorable effects of DHA include reducing inflammation, lowering serum triglycerides, reducing blood pressure, reducing beta amyloid production, reducing oxidation, reducing brain shrinkage, improving neurotransmission23, improving nerve myelination23 and lowering risk of thrombosis19,22.  One study reported that the group with the highest plasma DHA levels had 65% reduced chance of all-cause dementia and a 60-72% reduced chance of Alzheimer’s disease23.  Another study (included in this section) by Yurko-Mauro of 500 adults over 55 years of age with age-related cognitive decline given DHA daily showed improved cognitive testing that correlates to 7 years lower cognitive age23,24.

Pine Bark Extract

Pine bark extract has many beneficial effects including as an anti-oxidant25,26,28,31 (by doubling intracellular synthesis of anti-oxidants, by regenerating and protecting vitamin C and E, and by being a potent scavenger of damaging free radicals)25,27, anti-inflammatory25, prevents pain25, anti-viral, anti-microbial, stimulates the immune system, protects arteries, prevents leaking in blood vessels, and relaxes blood vessels25,26.  Studies showed improvement in a variety of aspects of cognition including speed of response, spatial working memory, immediate recognition tasks26, mini-tasks27, improved mood27, daily tasks28, cognitive function28, fatigue29, concentration29, sleeping29, memory29,30, irritability29, sustained attention30, executive function30, and enhanced synaptic plasticity31.  An 8 week study in students showed statistically significantly improved sustained attention, memory, executive function and mood with results graphed in this section30.

Lion’s Mane Mushroom

Lion‚Äôs mane mushroom has been used for thousands of years in Chinese medicine32.¬†¬†Lion‚Äôs mane is believed to contain over 70 potent bioactive compounds and many essential vitamins and minerals32.¬†¬†These compounds have been described as anti-aging32,35, neuroprotective32,33,35,37, anti-fatigue32, anti-diabetic32,36, anti-hypertensive32, anti-inflammatory32,35,39, anti-oxidant32,33,35,36,38, cardio-protective32,35,38, lowers blood cholesterol and improved lipids32,36,38, reduced pain32,36, decreases blood glucose and urine glucose32,36, improves anxiety32,35, improves cholesterol32,35, induces nerve growth32,33,35,37, repairs nerves32,33,35.37, increased nerve myelin sheath formation35, and increases cognitive function32,34.¬†¬†These processes are integral to maintaining normal brain function and preserving normal brain health32.¬†¬†Research suggests that supplementing with lion‚Äôs mane mushroom enhances cognitive function, improves spatial short-term and visual recognition memory35, reduces beta amyloid plaque deposits35,¬†¬†improves memory processing, improves general brain function in older adults and can stave off age related decline in cognitive health and function32,34.¬†¬†A double-blind placebo-controlled trial of 30 adults 50-80 years of age who had mild cognitive impairment given Lion‚Äôs mane mushroom or placebo for 16 weeks showed statistically significant improvements (p<0.001) in cognitive function and group-by-period interaction in those taking Lion‚Äôs mane compared to those on placebo34.¬†¬†Every individual domain in the cognitive test showed improvement over baseline for those taking Lions mane mushroom34.¬†¬†71% of those taking Lions mane mushroom were ‚Äėnotably improved‚Äô.34

L-theanine (green tea plant extract)

L-theanine is an amino acid that plays vital roles in enhancing brain performance.  L-theanine increases attention and alertness40,44,46,48,49,51,52, relaxes the mind44,49,52, reduces stress and anxiety40,44,49,51,52,53, reduces cholesterol54, reduces mind wandering41,44,48,49, is anti-oxidant43,45,50,54, anti-inflammatory43, neuroprotective43,45.50,54, increases mental clarity44,48,51, increases dopamine43,50 (a neurotransmitter important for feeling good) and enhances cognitive function44,46,48,49,53.  It also may promote restorative sleep47,51,53, reduce toxins50, prevent and reduce memory loss40,44,48,51,54, improve math42,46,51, increase executive function42,49,51, and enhance the body’s immune response to fight disease. 

There are 49 published studies of green tea benefits in humans40,44.  A double-blind crossover study in 12 habitual consumers showed improvements in Stroop score, Serial 3s subtraction and Serial 7s subtraction from baseline when on L-theanine as charted in this section55.  Stroop test is a computer test where colors are written in in words in a different color ink than the word.  Respondents must identify the color of the ink, not the word written.  Serial subtraction involves starting at 100 and subtracting by 3 for Serial 3s subtraction or by 7 for Serial 7s subtraction.

Tamarisk Tree

The tamarisk tree is a potent anti-oxidant and free radical scavenger59,60,62,63,64 that improves lipid profiles56, decreases harmful serum cholesterol56,58, reduces blood glucose62, is anti-microbial57,59, and potentially protects cells58,60 and stops cell death60  It inhibits beta amyloid aggregation61,64 and human islet amyloid peptide (hIAPP) aggregation61 expected to be helpful in Alzheimer‚Äôs disease61,64, cognitive impairment and diabetes56,61,62,63.  Tamarisk contains multiple polyphenols and flavonoids59,60,61,63.  10 flavonoids from the tamarisk tree all were shown to suppress aggregation of amyloid (the hallmark sign of Alzheimer‚Äôs disease), inhibited hIAPP (the hallmark sign of diabetes) and reduced harmful free radicals as shown in this section61.  These flavonoids are found in green vegetables, citrus fruits, berries, nuts, beans, onion and garlic65.

Ginkgo biloba

Ginkgo biloba is a traditional Chinese medicine and supplement that is well known for its benefits to cognitive function.¬† A ginkgo biloba extract (EGb¬† 761¬ģ) is approved throughout Europe for the symptomatic treatment of adults with cognitive impairment and mild-to-moderate dementia75.¬† Key properties include that it is an anti-oxidant67,71, free radical scavenger67,71, reduces blood sugar71, reduces lipids71, improves glucose regulation71, delays diabetes71, regulates insulin secretion71, reduces cardiovascular disease71, improves blood circulation67,71, modifies neurotransmitters67, facilitates memory72, reduces cardiovascular reactivity to cognitive tasks67, inhibits inflammation71, improves insulin resistance71, reduces depression70, reduces errors (on card classification test)70, reduces caregiver distress74, improves motor function and coordination73, is neuroprotective70,73, improves memory71¬†and improves cognition71¬†.¬†

A meta-analysis of controlled clinical trials identified 21 trials with 2608 patients that showed that ginkgo improved cognitive function (by Mini-Mental State Examination) in Alzheimer’s disease and mild cognitive impairment66.  Ginkgo biloba also improved activities of daily living in Alzheimer’s patients66, 68, 69.  In a double-blind, placebo crossover study, ginkgo improved Stroop and Berg tasks (measures of executive function)67.  In the randomized controlled trials charted below, ginkgo biloba had almost twice as many responders as placebo (responder defined as >2 point decrease on ADAS-cog from baseline)75 and was significantly more effective than placebo in improving cognition as measured by changes from baseline in Syndrom-Kurz test (SKT; a psychometric test that assesses memory and attention) 75.


Resveratrol is a naturally occurring phenol found in grape skins and berries that is neuroprotective against cognitive impairment76, 77, 78, 80, 81, 82, 84, can delay age-related cognitive decline76, 78, 80, 81, 82, 84, supports healthy expression of genes associated with slowing aging81, 82, inhibits oxidative stress76, 77, 81, 82, reduces inflammation76, 81, 82, cross the blood-brain barrier and increases brain blood flow76, 78, 79, 80, 83, improves neuroplasticity76, 82,, induces autophagy, 76, 81, 82, decreases beta amyloid 81, 82, promotes cardiovascular health, encourages healthy insulin sensitivity and mitochondrial function,81, 82, 84, protects against Alzheimer’s disease, 81, 82, and enhances brain health through a number of different mechanisms76, 77, 81, 82. 

Placebo-controlled studies showed that resveratrol improved psychomotor speed, cognitive performance78, 79, 81, 83, executive function79, and long-term memory78, 79.  Statistically significant improvements in cognition and verbal memory from resveratrol in a 14-week randomized, placebo-controlled trial are charted in this section83.

EPA (eicosapentaenoic acid from omega 3 fish oil)

EPA is an omega-3 that is an essential nutrient that enhances quality of life and lowers risk of premature death 86 . EPA influences behavior and mood and is neuroprotective 86,99 . Studies of DHA and EPA combined benefited Attention Deficit/Hyperactivity Disorder (ADHD), depression, autism, dyslexia, attention, vigilance and aggression 86,99,100. Accelerated cognitive decline and mild cognitive impairment (MCI) correlate with lowered EPA/DHA and supplementation improved cognitive function 86,87. Increasing EPA/DHA intake may reduce risk of progressing to dementia 87. Since our bodies don‚Äôt produce EPA or DHA, it is necessary to consume adequate amounts 88. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in very mild Alzheimer‚Äôs disease 88. EPA appears to reduce amyloid-ő≤ deposits, neuron loss and improves cognitive function. Brain structure and function depend on consistent, sufficient EPA and DHA. Low omega-3s were associated with increased risk for total mortality and ischemic stroke, reduced brain volume, impaired cognition, accelerated progression to dementia, and compromise of complex brain functions88. Higher EPA and DHA levels correlated with larger brain volume 89. EPA supplementation allowed participants‚Äô brains to work ‚Äėless hard‚Äô and achieve better cognitive performance 90, faster reaction times 91,99,100 and improved working memory 93. These benefits may be mediated through anti-inflammatory 86,88,95 and anti-oxidant effects 94,95 and improvements in blood sugar and lipid profiles 95. EPA and DHA also reduce the risk of cardiovascular disease, heart attacks and cardiovascular mortality. Zutphen Elderly Study showed higher EPA/DHA the lower the rate of cognitive decline in a linear relationship (shown) 96,97. Kalmijn et al tested 1613 people and followed them for 5 years. Those with the most cognitive impairment had the lowest intake of EPA/DHA 96,98. Fontani study showed EPA/DHA improved mood and attention and reduced reaction time (shown) 100.

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Vivolor¬ģ Memory Support is a powerful nutraceutical containing many of the nutrients found in vegetables, fruit, nuts, seeds and healthy fish. It provides 5000mg per day of the most scientifically documented memory support supplements.¬†¬†Vivolor Memory Support utilizes a proprietary formula and patented method to enhance and optimize the effects of its naturally brain-boosting ingredients.¬† Take charge of your brain health today with Vivolor Memory Support!


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  3. Protective effects of Bacopa monnieri on ischemia-induced cognitive deficits in mice: The possible contribution of bacopaside I and underlying mechanism
  4. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model
  5. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: Implications in memory formation
  6. Examining the cognitive effects of a special extract of Bacopa Monniera (CDRI 08:KeenMind): A Review of 10 years of Research at Swinburne University
  7. Bacopa monniera, a reputed nootropic plant: an overview
  8. Neuroprotective effect of Bacopa monnieri on beta-amyloid induced cell death in primary cortical culture
  9. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects
  10. Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease
  11. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
  12. Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain.
  13. Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress
  14. Curcumin Improves Amyloid ő≤-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway
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  28. The COFU3 Study. Improvement in cognitive function, attention, mental performance with Pycnogenol¬ģ in healthy subjects (55-70) with high oxidative stress
  29. Supplementation with Pycnogenol¬ģ improves signs and symptoms of menopausal transition
  30. Pycnogenol¬ģ supplementation improves cognitive function, attention and mental performance in students
  31. Cognitive assessment of pycnogenol therapy following traumatic brain injury
  32. Benefits of Lion’s Mane Mushroom
  33. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia
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  36. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats
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  57. Identification of oral cavity biofilm forming bacteria and determination of their growth inhibition by Acacia arabica, Tamarix aphylla L. and Melia azedarach L. medicinal plants
  58. The Role of Tamarix gallica Leaves Extract in Liver Injury Induced by Rifampicin Plus Isoniazid in Sprague Dawley Rats
  59. Chemical composition, antioxidant and antibacterial activities of Tamarix balansae J. Gay aerial parts
  60. Tamarix gallica phenolics protect IEC-6 cells against H2O2 induced stress by restricting oxidative injuries and MAPKs signaling pathways
  61. Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer’s and Type 2 Diabetes Diseases
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  64. Site-specific Inhibitory Mechanism for Amyloid ő≤42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues
  65. List of Foods With Flavinoids
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  70. Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B
  71. Efficacy and Safety of Ginkgo Biloba Pills for Coronary Heart Disease with Impaired Glucose Regulation: Study Protocol for a Series of N-of-1 Randomized, Double-Blind, Placebo-Controlled Trials
  72. Effects of standardized Ginkgo biloba extract on the acquisition, retrieval and extinction of conditioned suppression: Evidence that short-term memory and long-term memory are differentially modulated
  73. Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats
  74. Treatment effects of Ginkgo biloba extract EGb 761¬ģ on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials
  75. Ginkgo biloba extract EGb¬† 761¬ģ in¬†the¬†symptomatic treatment of¬†mild‚ÄĎto‚ÄĎmoderate dementia: a¬†profile of¬†its use
  76. Resveratrol Boosts Cognitive Function by Targeting SIRT1
  77. Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain
  78. Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats
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  89. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study – PubMed (
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