Product Evidence

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Vivolor® Memory Support’s ingredients are naturally grown and proven to be helpful, sustainable and Generally Regarded As Safe (GRAS) by the FDA. Below is science-based evidence supporting each ingredient’s ability to improve memory and cognition plus provide mega-nutrients to the brain. Vivolor products have not been evaluated for their effectiveness in treating the health conditions described herein.

Bacopa

Bacopa is an Indian herb used for centuries that enhances memory^{1,2,3,4,5,6,7}, protects nerves^1,3,4,6,8, reduces inflammation^1,6,7, improves intelligence^3,4, reduces oxidation^1,6,8, relieves pain^1,7, improves learning^2,4,5, prevents cognitive deficits^1,3,4,6, increases brain blood flow⁶, increases energy metabolism⁶, improves information processing speed^1,6, reduces beta amyloid plaques^1,8, increases acetylcholine^4,8, and improves brain function^6,8. There are numerous studies of bacopa in labs, animals, and humans. 289 human studies were identified, of which 9 studies were randomized, placebo-controlled human trials (the highest level of evidence) of chronic use (12 or more weeks of treatment) of bacopa including 518 subjects¹. These studies showed that bacopa monnieri has the potential to improve cognitive performance and decrease choice reaction time (a measure of speed and attention).¹ In cultured neurons, bacopa protected neurons from beta-amyloid induced cell death, suppressed acetylcholinesterase, and promoted cell survival.⁵

The charts display the results of a double-blind, placebo-controlled study of bacopa in 46 healthy volunteers age 18-60 after 12 weeks of dosing at Swinburne University⁹. Results of the AVLT (Auditory Verbal Learning Test) indicated statically significantly improved speed of information processing, improved learning, improved memory (decreased forgetting and decreased proactive interference), reduced inspection time, and reduced anxiety.⁹

Curcumin (from turmeric root)

Curcumin is an amazing herbal supplement that provides numerous health benefits. Curcumin is a potent anti-oxidant^{10,11,12,14,15,16,18}, anti-inflammatory^{10,11,14,15,18}, enhances cognition^{10,11,12,13,14.16}, prevents neurodegeneration^10,11,15, reduces beta amyloid plaques^10,11,17,18, improves attention¹¹, increases alertness¹¹, enhances memory^11,13, improves mood^11,13,15, improves lipids and cholesterol¹¹, improves mitochondrial function¹², enhances neuron function¹², promotes neurogenesis and neural plasticity¹¹, beneficially influences neurotransmitters¹¹, increases neurotrophic factor and signaling kinases^13,14, reduces mental fatigue^11,16, increases calmness^11,16, and showed 50% reduction in beta amyloid plaques¹⁷. The Achilles heel of native curcumin is that absorption into the body is typically less than 1%. That means if you take 100mg, less than 1mg gets into your body! Glory Day^TM Brain Booster has a novel, patent protected method of dramatically enhancing absorption over 185 times in comparison to native curcumin so that you can benefit from curcumin’s excellent health promoting properties!

The charts show results of a randomized, double-blind, placebo-controlled study of curcumin with enhanced bioavailability in 61 healthy individuals age 60-85. Digit Vigilance Tests measure sustained attention and psychomotor speed and involve finding and crossing out sixes or nines which appear randomly within 59 rows of single digits in a 10 minute timed test.

Curcumin statistically significantly improved accuracy, improved math (subtraction), increased calmness, enhanced contentedness and reduced fatigue^11.Lipids were significantly improved (reduced cholesterol and reduced low density lipoproteins (LDL)) with chronic use of curcumin.¹¹

DHA (docosahexaenoic acid from omega 3 fish oil)

Your brain is 60% fat and DHA is the largest component of that fat which is naturally occurring in human brains. DHA is the most important and powerful natural fat in our brain and decreases with age after 20 years of age¹⁹. Your body cannot make DHA, so it is critical to consume DHA in a supplement. DHA in the brain is greatly decreased in Alzheimer’s disease¹⁹. In longitudinal studies, increased levels of DHA correlated with decreased cognitive decline¹⁹. In numerous studies, consistent DHA taken long-term reduced beta amyloid deposits, reduced loss of hippocampal neurons and improved cognitive function in rats¹⁹. DHA has also been correlated with higher brain volume (less shrinking of the brain which is typical of dementia) in humans¹⁹. CDC recommends 2-3 fish meals per week or the equivalent intake of fatty acids, particularly DHA¹⁹. In the Framingham Study, decreased DHA was related to subsequent cognitive decline^19,20. The top quartile with the highest plasma DHA had statistically significant 47% reduction in the risk of developing dementia from any cause after 9 years of follow up^19,20. A dose-response relationship was observed between DHA serum levels and cognitive performance scores^23,85. Higher DHA levels were associated with better scores on non-verbal reasoning, mental flexibility, working memory and vocabulary^23,85. DHA improves visual memory, abstract skills, immediate recall, short term memory, working memory^19,20,23, verbal memory, semantic memory function²¹, delayed recall, non-verbal reasoning²³, mental flexibility²³, vocabulary²³, attention, speed and executive function^19,20. Favorable effects of DHA include reducing inflammation, lowering serum triglycerides, reducing blood pressure, reducing beta amyloid production, reducing oxidation, reducing brain shrinkage, improving neurotransmission²³, improving nerve myelination²³ and lowering risk of thrombosis^19,22. One study reported that the group with the highest plasma DHA levels had 65% reduced chance of all-cause dementia and a 60-72% reduced chance of Alzheimer’s disease²³. Another study (included in this section) by Yurko-Mauro of 500 adults over 55 years of age with age-related cognitive decline given DHA daily showed improved cognitive testing that correlates to 7 years lower cognitive age^23,24.

Pine Bark Extract

Pine bark extract has many beneficial effects including as an anti-oxidant^25,26,28,31 (by doubling intracellular synthesis of anti-oxidants, by regenerating and protecting vitamin C and E, and by being a potent scavenger of damaging free radicals)^25,27, anti-inflammatory²⁵, prevents pain²⁵, anti-viral, anti-microbial, stimulates the immune system, protects arteries, prevents leaking in blood vessels, and relaxes blood vessels^25,26. Studies showed improvement in a variety of aspects of cognition including speed of response, spatial working memory, immediate recognition tasks²⁶, mini-tasks²⁷, improved mood²⁷, daily tasks²⁸, cognitive function²⁸, fatigue²⁹, concentration²⁹, sleeping²⁹, memory^29,30, irritability²⁹, sustained attention³⁰, executive function³⁰, and enhanced synaptic plasticity³¹. An 8 week study in students showed statistically significantly improved sustained attention, memory, executive function and mood with results graphed in this section³⁰.

Lion’s Mane Mushroom

Lion’s mane mushroom has been used for thousands of years in Chinese medicine³². Lion’s mane is believed to contain over 70 potent bioactive compounds and many essential vitamins and minerals³². These compounds have been described as anti-aging^32,35, neuroprotective^32,33,35,37, anti-fatigue³², anti-diabetic^32,36, anti-hypertensive³², anti-inflammatory^32,35,39, anti-oxidant^{32,33,35,36,38}, cardio-protective^32,35,38, lowers blood cholesterol and improved lipids^32,36,38, reduced pain^32,36, decreases blood glucose and urine glucose^32,36, improves anxiety^32,35, improves cholesterol^32,35, induces nerve growth^32,33,35,37, repairs nerves^32,33,35.37, increased nerve myelin sheath formation³⁵, and increases cognitive function^32,34. These processes are integral to maintaining normal brain function and preserving normal brain health³². Research suggests that supplementing with lion’s mane mushroom enhances cognitive function, improves spatial short-term and visual recognition memory³⁵, reduces beta amyloid plaque deposits³⁵, improves memory processing, improves general brain function in older adults and can stave off age related decline in cognitive health and function^32,34. A double-blind placebo-controlled trial of 30 adults 50-80 years of age who had mild cognitive impairment given Lion’s mane mushroom or placebo for 16 weeks showed statistically significant improvements (p<0.001) in cognitive function and group-by-period interaction in those taking Lion’s mane compared to those on placebo³⁴. Every individual domain in the cognitive test showed improvement over baseline for those taking Lions mane mushroom³⁴. 71% of those taking Lions mane mushroom were ‘notably improved’.³⁴

L-theanine (green tea plant extract)

L-theanine is an amino acid that plays vital roles in enhancing brain performance. L-theanine increases attention and alertness^{40,44,46,48,49,51,52}, relaxes the mind^44,49,52, reduces stress and anxiety^{40,44,49,51,52,53}, reduces cholesterol⁵⁴, reduces mind wandering^41,44,48,49, is anti-oxidant^43,45,50,54, anti-inflammatory⁴³, neuroprotective^43,45.50,54, increases mental clarity^44,48,51, increases dopamine^43,50 (a neurotransmitter important for feeling good) and enhances cognitive function^{44,46,48,49,53}. It also may promote restorative sleep^47,51,53, reduce toxins⁵⁰, prevent and reduce memory loss^{40,44,48,51,54}, improve math^42,46,51, increase executive function^42,49,51, and enhance the body’s immune response to fight disease.

There are 49 published studies of green tea benefits in humans^40,44. A double-blind crossover study in 12 habitual consumers showed improvements in Stroop score, Serial 3s subtraction and Serial 7s subtraction from baseline when on L-theanine as charted in this section⁵⁵. Stroop test is a computer test where colors are written in in words in a different color ink than the word. Respondents must identify the color of the ink, not the word written. Serial subtraction involves starting at 100 and subtracting by 3 for Serial 3s subtraction or by 7 for Serial 7s subtraction.

Tamarisk Tree

The tamarisk tree is a potent anti-oxidant and free radical scavenger^{59,60,62,63,64} that improves lipid profiles⁵⁶, decreases harmful serum cholesterol^56,58, reduces blood glucose⁶², is anti-microbial^57,59, and potentially protects cells^58,60 and stops cell death⁶⁰. It inhibits beta amyloid aggregation^61,64 and human islet amyloid peptide (hIAPP) aggregation⁶¹ expected to be helpful in Alzheimer’s disease^61,64, cognitive impairment and diabetes^56,61,62,63. Tamarisk contains multiple polyphenols and flavonoids^59,60,61,63. 10 flavonoids from the tamarisk tree all were shown to suppress aggregation of amyloid (the hallmark sign of Alzheimer’s disease), inhibited hIAPP (the hallmark sign of diabetes) and reduced harmful free radicals as shown in this section⁶¹. These flavonoids are found in green vegetables, citrus fruits, berries, nuts, beans, onion and garlic⁶⁵.

Ginkgo biloba

Ginkgo biloba is a traditional Chinese medicine and supplement that is well known for its benefits to cognitive function. A ginkgo biloba extract (EGb 761®) is approved throughout Europe for the symptomatic treatment of adults with cognitive impairment and mild-to-moderate dementia⁷⁵. Key properties include that it is an anti-oxidant^67,71, free radical scavenger^67,71, reduces blood sugar⁷¹, reduces lipids⁷¹, improves glucose regulation⁷¹, delays diabetes⁷¹, regulates insulin secretion⁷¹, reduces cardiovascular disease⁷¹, improves blood circulation^67,71, modifies neurotransmitters⁶⁷, facilitates memory⁷², reduces cardiovascular reactivity to cognitive tasks⁶⁷, inhibits inflammation⁷¹, improves insulin resistance⁷¹, reduces depression⁷⁰, reduces errors (on card classification test)⁷⁰, reduces caregiver distress⁷⁴, improves motor function and coordination⁷³, is neuroprotective^70,73, improves memory⁷¹ and improves cognition⁷¹ .

A meta-analysis of controlled clinical trials identified 21 trials with 2608 patients that showed that ginkgo improved cognitive function (by Mini-Mental State Examination) in Alzheimer’s disease and mild cognitive impairment⁶⁶. Ginkgo biloba also improved activities of daily living in Alzheimer’s patients^{66, 68, 69}. In a double-blind, placebo crossover study, ginkgo improved Stroop and Berg tasks (measures of executive function)⁶⁷. In the randomized controlled trials charted below, ginkgo biloba had almost twice as many responders as placebo (responder defined as >2 point decrease on ADAS-cog from baseline)⁷⁵and was significantly more effective than placebo in improving cognition as measured by changes from baseline in Syndrom-Kurz test (SKT; a psychometric test that assesses memory and attention)⁷⁵.

Resveratrol

Resveratrol is a naturally occurring phenol found in grape skins and berries that is neuroprotective against cognitive impairment^{76, 77, 78, 80, 81, 82, 84}, can delay age-related cognitive decline^{76, 78, 80, 81, 82, 84}, supports healthy expression of genes associated with slowing aging^{81, 82}, inhibits oxidative stress^{76, 77, 81, 82}, reduces inflammation^{76, 81, 82}, cross the blood-brain barrier and increases brain blood flow^{76, 78, 79, 80, 83}, improves neuroplasticity^{76, 82},^,induces autophagy^{, 76, 81, 82}, decreases beta amyloid^{81, 82}, promotes cardiovascular health, encourages healthy insulin sensitivity and mitochondrial function^{,81, 82, 84}, protects against Alzheimer’s disease^{, 81, 82}, and enhances brain health through a number of different mechanisms^{76, 77, 81, 82}.

Placebo-controlled studies showed that resveratrol improved psychomotor speed, cognitive performance^{78, 79, 81, 83}, executive function⁷⁹, and long-term memory^{78, 79}. Statistically significant improvements in cognition and verbal memory from resveratrol in a 14-week randomized, placebo-controlled trial are charted in this section⁸³.

EPA (eicosapentaenoic acid from omega 3 fish oil)

EPA is an omega-3 that is an essential nutrient that enhances quality of life and lowers risk of premature death ⁸⁶ . EPA influences behavior and mood and is neuroprotective ^86,99 . Studies of DHA and EPA combined benefited Attention Deficit/Hyperactivity Disorder (ADHD), depression, autism, dyslexia, attention, vigilance and aggression ^86,99,100. Accelerated cognitive decline and mild cognitive impairment (MCI) correlate with lowered EPA/DHA and supplementation improved cognitive function ^86,87. Increasing EPA/DHA intake may reduce risk of progressing to dementia ⁸⁷. Since our bodies don’t produce EPA or DHA, it is necessary to consume adequate amounts ⁸⁸. EPA and DHA have been linked to promising results in prevention, weight management, and cognitive function in very mild Alzheimer’s disease ⁸⁸. EPA appears to reduce amyloid-β deposits, neuron loss and improves cognitive function. Brain structure and function depend on consistent, sufficient EPA and DHA. Low omega-3s were associated with increased risk for total mortality and ischemic stroke, reduced brain volume, impaired cognition, accelerated progression to dementia, and compromise of complex brain functions⁸⁸. Higher EPA and DHA levels correlated with larger brain volume ⁸⁹. EPA supplementation allowed participants’ brains to work ‘less hard’ and achieve better cognitive performance ⁹⁰, faster reaction times ^91,99,100 and improved working memory ⁹³. These benefits may be mediated through anti-inflammatory ^86,88,95 and anti-oxidant effects ⁹⁴,⁹⁵ and improvements in blood sugar and lipid profiles ⁹⁵. EPA and DHA also reduce the risk of cardiovascular disease, heart attacks and cardiovascular mortality. Zutphen Elderly Study showed higher EPA/DHA the lower the rate of cognitive decline in a linear relationship (shown) ^96,97. Kalmijn et al tested 1613 people and followed them for 5 years. Those with the most cognitive impairment had the lowest intake of EPA/DHA ^96,98. Fontani study showed EPA/DHA improved mood and attention and reduced reaction time (shown) ¹⁰⁰.

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Description

Description

Vivolor® Memory Support is a powerful nutraceutical containing many of the nutrients found in vegetables, fruit, nuts, seeds and healthy fish. It provides 5000mg per day of the most scientifically documented memory support supplements. Vivolor Memory Support utilizes a proprietary formula and patented method to enhance and optimize the effects of its naturally brain-boosting ingredients. Take charge of your brain health today with Vivolor Memory Support!

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