Glory Day® Brain Booster contains the most powerful agents to improve memory and provide mega-nutrients for the brain, utilizing a novel, patent-protected method of enhancing the body’s ability to utilize ingredients. All ingredients are Generally Regarded As Safe (GRAS) by the FDA. Vivolor® Therapeutics takes product evidence seriously. Below are data supporting each ingredient. Vivolor products have not been evaluated for their effectiveness in treating the health conditions described herein.
Bacopa is an Indian herb used for centuries that enhances memory1,2,3,4,5,6,7, protects nerves1,3,4,6,8, reduces inflammation1,6,7, improves intelligence3,4, reduces oxidation1,6,8, relieves pain1,7, improves learning2,4,5, prevents cognitive deficits1,3,4,6, increases brain blood flow6, increases energy metabolism6, improves information processing speed1,6, reduces beta amyloid plaques1,8, increases acetylcholine4,8, and improves brain function6,8. There are numerous studies of bacopa in labs, animals, and humans. 289 human studies were identified, of which 9 studies were randomized, placebo-controlled human trials (the highest level of evidence) of chronic use (12 or more weeks of treatment) of bacopa including 518 subjects1. These studies showed that bacopa monnieri has the potential to improve cognitive performance and decrease choice reaction time (a measure of speed and attention). 1 In cultured neurons, bacopa protected neurons from beta-amyloid induced cell death, suppressed acetylcholinesterase, and promoted cell survival. 5
The charts display the results of a double-blind, placebo-controlled study of bacopa in 46 healthy volunteers age 18-60 after 12 weeks of dosing at Swinburne University9. Results of the AVLT (Auditory Verbal Learning Test) indicated statically significantly improved speed of information processing, improved learning, improved memory (decreased forgetting and decreased proactive interference), reduced inspection time, and reduced anxiety. 9
Curcumin (from turmeric root)
Curcumin is an amazing herbal supplement that provides numerous health benefits. Curcumin is a potent anti-oxidant10,11,12,14,15,16,18, anti-inflammatory10,11,14,15,18, enhances cognition10,11,12,13,14.16, prevents neurodegeneration10,11,15, reduces beta amyloid plaques10,11,17,18, improves attention11, increases alertness11, enhances memory11,13, improves mood11,13,15, improves lipids and cholesterol11, improves mitochondrial function12, enhances neuron function12, promotes neurogenesis and neural plasticity11, beneficially influences neurotransmitters11, increases neurotrophic factor and signaling kinases13,14, reduces mental fatigue11,16, increases calmness11,16, and showed 50% reduction in beta amyloid plaques17. The Achilles heel of native curcumin is that absorption into the body is typically less than 1%. That means if you take 100mg, less than 1mg gets into your body! Glory DayTM Brain Booster has a novel, patent protected method of dramatically enhancing absorption over 185 times in comparison to native curcumin so that you can benefit from curcumin’s excellent health promoting properties!
The charts show results of a randomized, double-blind, placebo-controlled study of curcumin with enhanced bioavailability in 61 healthy individuals age 60-85. Digit Vigilance Tests measure sustained attention and psychomotor speed and involve finding and crossing out sixes or nines which appear randomly within 59 rows of single digits in a 10 minute timed test.
Curcumin statistically significantly improved accuracy, improved math (subtraction), increased calmness, enhanced contentedness and reduced fatigue11. Lipids were significantly improved (reduced cholesterol and reduced low density lipoproteins (LDL)) with chronic use of curcumin.11
DHA (docosahexaenoic acid from omega 3 fish oil)
Your brain is 60% fat and DHA is the largest component of that fat which is naturally occurring in human brains. DHA is the most important and powerful natural fat in our brain and decreases with age after 20 years of age19. Your body cannot make DHA, so it is critical to consume DHA in a supplement. DHA in the brain is greatly decreased in Alzheimer’s disease19. In longitudinal studies, increased levels of DHA correlated with decreased cognitive decline19. In numerous studies, consistent DHA taken long-term reduced beta amyloid deposits, reduced loss of hippocampal neurons and improved cognitive function in rats19. DHA has also been correlated with higher brain volume (less shrinking of the brain which is typical of dementia) in humans19. CDC recommends 2-3 fish meals per week or the equivalent intake of fatty acids, particularly DHA19. In the Framingham Study, decreased DHA was related to subsequent cognitive decline19,20. The top quartile with the highest plasma DHA had statistically significant 47% reduction in the risk of developing dementia from any cause after 9 years of follow up19,20. DHA improves visual memory, abstract skills, immediate recall, short term memory, working memory19,20,23, verbal memory, semantic memory function21, delayed recall, non-verbal reasoning23, mental flexibility23, vocabulary23, attention, speed and executive function19,20. Favorable effects of DHA include reducing inflammation, lowering serum triglycerides, reducing blood pressure, reducing beta amyloid production, reducing oxidation, reducing brain shrinkage, improving neurotransmission23, improving nerve myelination23 and lowering risk of thrombosis19,22. One study reported that the group with the highest plasma DHA levels had 65% reduced chance of all-cause dementia and a 60-72% reduced chance of Alzheimer’s disease23. Another study (included in this section) by Yurko-Mauro of 500 adults over 55 years of age with age-related cognitive decline given DHA daily showed improved cognitive testing that correlates to 7 years lower cognitive age23,24.
Pine Bark Extract
Pine bark extract has many beneficial effects including as an anti-oxidant25,26,28,31 (by doubling intracellular synthesis of anti-oxidants, by regenerating and protecting vitamin C and E, and by being a potent scavenger of damaging free radicals)25,27, anti-inflammatory25, prevents pain25, anti-viral, anti-microbial, stimulates the immune system, protects arteries, prevents leaking in blood vessels, and relaxes blood vessels25,26. Studies showed improvement in a variety of aspects of cognition including speed of response, spatial working memory, immediate recognition tasks26, mini-tasks27, improved mood27, daily tasks28, cognitive function28, fatigue29, concentration29, sleeping29, memory29,30, irritability29, sustained attention30, executive function30, and enhanced synaptic plasticity31. An 8 week study in students showed statistically significantly improved sustained attention, memory, executive function and mood with results graphed in this section30.
Lion’s Mane Mushroom
Lion’s mane mushroom has been used for thousands of years in Chinese medicine32. Lion’s mane is believed to contain over 70 potent bioactive compounds and many essential vitamins and minerals32. These compounds have been described as anti-aging32,35, neuroprotective32,33,35,37, anti-fatigue32, anti-diabetic32,36, anti-hypertensive32, anti-inflammatory32,35,39, anti-oxidant32,33,35,36,38, cardio-protective32,35,38, lowers blood cholesterol and improved lipids32,36,38, reduced pain32,36, decreases blood glucose and urine glucose32,36, improves anxiety32,35, improves cholesterol32,35, induces nerve growth32,33,35,37, repairs nerves32,33,35.37, increased nerve myelin sheath formation35, and increases cognitive function32,34. These processes are integral to maintaining normal brain function and preserving normal brain health32. Research suggests that supplementing with lion’s mane mushroom enhances cognitive function, improves spatial short-term and visual recognition memory35, reduces beta amyloid plaque deposits35, improves memory processing, improves general brain function in older adults and can stave off age related decline in cognitive health and function32,34. A double-blind placebo-controlled trial of 30 adults 50-80 years of age who had mild cognitive impairment given Lion’s mane mushroom or placebo for 16 weeks showed statistically significant improvements (p<0.001) in cognitive function and group-by-period interaction in those taking Lion’s mane compared to those on placebo34. Every individual domain in the cognitive test showed improvement over baseline for those taking Lions mane mushroom34. 71% of those taking Lions mane mushroom were ‘notably improved’.34
L-theanine (green tea plant extract)
L-theanine is an amino acid that plays vital roles in enhancing brain performance. L-theanine increases attention and alertness40,44,46,48,49,51,52, relaxes the mind44,49,52, reduces stress and anxiety40,44,49,51,52,53, reduces cholesterol54, reduces mind wandering41,44,48,49, is anti-oxidant43,45,50,54, anti-inflammatory43, neuroprotective43,45.50,54, increases mental clarity44,48,51, increases dopamine43,50 (a neurotransmitter important for feeling good) and enhances cognitive function44,46,48,49,53. It also may promote restorative sleep47,51,53, reduce toxins50, prevent and reduce memory loss40,44,48,51,54, improve math42,46,51, increase executive function42,49,51, and enhance the body’s immune response to fight disease.
There are 49 published studies of green tea benefits in humans40,44. A double-blind crossover study in 12 habitual consumers showed improvements in Stroop score, Serial 3s subtraction and Serial 7s subtraction from baseline when on L-theanine as charted in this section55. Stroop test is a computer test where colors are written in in words in a different color ink than the word. Respondents must identify the color of the ink, not the word written. Serial subtraction involves starting at 100 and subtracting by 3 for Serial 3s subtraction or by 7 for Serial 7s subtraction.
The tamarisk tree is a potent anti-oxidant and free radical scavenger59,60,62,63,64 that improves lipid profiles56, decreases harmful serum cholesterol56,58, reduces blood glucose62, is anti-microbial57,59, and potentially protects cells58,60 and stops cell death60. It inhibits beta amyloid aggregation61,64 and human islet amyloid peptide (hIAPP) aggregation61 expected to be helpful in Alzheimer’s disease61,64, cognitive impairment and diabetes56,61,62,63. Tamarisk contains multiple polyphenols and flavonoids59,60,61,63. 10 flavonoids from the tamarisk tree all were shown to suppress aggregation of amyloid (the hallmark sign of Alzheimer’s disease), inhibited hIAPP (the hallmark sign of diabetes) and reduced harmful free radicals as shown in this section61. These flavonoids are found in green vegetables, citrus fruits, berries, nuts, beans, onion and garlic65.
Ginkgo biloba is a traditional Chinese medicine and supplement that is well known for its benefits to cognitive function. A ginkgo biloba extract (EGb 761®) is approved throughout Europe for the symptomatic treatment of adults with cognitive impairment and mild-to-moderate dementia75. Key properties include that it is an anti-oxidant67,71, free radical scavenger67,71, reduces blood sugar71, reduces lipids71, improves glucose regulation71, delays diabetes71, regulates insulin secretion71, reduces cardiovascular disease71, improves blood circulation67,71, modifies neurotransmitters67, facilitates memory72, reduces cardiovascular reactivity to cognitive tasks67, inhibits inflammation71, improves insulin resistance71, reduces depression70, reduces errors (on card classification test)70, reduces caregiver distress74, improves motor function and coordination73, is neuroprotective70,73, improves memory71 and improves cognition71 .
A meta-analysis of controlled clinical trials identified 21 trials with 2608 patients that showed that ginkgo improved cognitive function (by Mini-Mental State Examination) in Alzheimer’s disease and mild cognitive impairment66. Ginkgo biloba also improved activities of daily living in Alzheimer’s patients66, 68, 69. In a double-blind, placebo crossover study, ginkgo improved Stroop and Berg tasks (measures of executive function)67. In the randomized controlled trials charted below, ginkgo biloba had almost twice as many responders as placebo (responder defined as >2 point decrease on ADAS-cog from baseline)75 and was significantly more effective than placebo in improving cognition as measured by changes from baseline in Syndrom-Kurz test (SKT; a psychometric test that assesses memory and attention) 75.
Resveratrol is a naturally occurring phenol found in grape skins and berries that is neuroprotective against cognitive impairment76, 77, 78, 80, 81, 82, 84, can delay age-related cognitive decline76, 78, 80, 81, 82, 84, supports healthy expression of genes associated with slowing aging81, 82, inhibits oxidative stress76, 77, 81, 82, reduces inflammation76, 81, 82, cross the blood-brain barrier and increases brain blood flow76, 78, 79, 80, 83, improves neuroplasticity76, 82,, induces autophagy, 76, 81, 82, decreases beta amyloid 81, 82, promotes cardiovascular health, encourages healthy insulin sensitivity and mitochondrial function,81, 82, 84, protects against Alzheimer’s disease, 81, 82, and enhances brain health through a number of different mechanisms76, 77, 81, 82.
Placebo-controlled studies showed that resveratrol improved psychomotor speed, cognitive performance78, 79, 81, 83, executive function79, and long-term memory78, 79. Statistically significant improvements in cognition and verbal memory from resveratrol in a 14-week randomized, placebo-controlled trial are charted in this section83.
- Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract
- Effect of Bacopa monniera Linn. (brahmi) extract on learning and memory in rats: A behavioral study
- Protective effects of Bacopa monnieri on ischemia-induced cognitive deficits in mice: The possible contribution of bacopaside I and underlying mechanism
- Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model
- Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: Implications in memory formation
- Examining the cognitive effects of a special extract of Bacopa Monniera (CDRI 08:KeenMind): A Review of 10 years of Research at Swinburne University
- Bacopa monniera, a reputed nootropic plant: an overview
- Neuroprotective effect of Bacopa monnieri on beta-amyloid induced cell death in primary cortical culture
- The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects
- Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease
- Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
- Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain.
- Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress
- Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway
- Curcumin for neuropsychiatric disorders: a review of in vitro, animal and human studies
- Cognitive decline and Alzheimer’s disease by Oregon State
- Dual targeting agents for Aβ plaque/P-glycoprotein and Aβ plaque/nicotinic acetylcholine α4β2* receptors-potential approaches to facilitate Aβ plaque removal in Alzheimer’s disease brain
- Curcumin and curcumin-like molecules: from spice to drugs
- Omega-3 Fatty Acids in the Prevention of Cognitive Decline in Humans
- Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
- Docosahexaenoic acid and adult memory: a systematic review and meta-analysis
- Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging
- Docosahexaenoic Acid and Cognition throughout the Lifespan
- Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
- A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology
- Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract formulation
- Pycnogenol® improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35-55
- The COFU3 Study. Improvement in cognitive function, attention, mental performance with Pycnogenol® in healthy subjects (55-70) with high oxidative stress
- Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition
- Pycnogenol® supplementation improves cognitive function, attention and mental performance in students
- Cognitive assessment of pycnogenol therapy following traumatic brain injury
- Benefits of Lion’s Mane Mushroom
- Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia
- Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
- Neurological Activity of Lion’s Mane (Hericium erinaceus)
- Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats
- Neuroregenerative Potential of Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Higher Basidiomycetes), in the Treatment of Peripheral Nerve Injury (Review)
- Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats
- Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages
- Green tea effects on cognition, mood and human brain function: A systematic review
- l-Theanine and caffeine improve target-specific attention to visual stimuli by decreasing mind wandering: a human functional magnetic resonance imaging study
- Cognitive and Mood Effects of a Nutrient Enriched Breakfast Bar in Healthy Adults: A Randomised, Double-Blind, Placebo-Controlled, Parallel Groups Study
- L-theanine prevent quinolinic acid induced motor deficit and striatal neurotoxicity: Reduction in oxido-nitrosative stress and restoration of striatal neurotransmitters level
- Effect of Green Tea Phytochemicals on Mood and Cognition
- l-Theanine attenuates cadmium-induced neurotoxicity through the inhibition of oxidative damage and tau hyperphosphorylation
- Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task
- The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial
- A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study
- L-theanine, a natural constituent in tea, and its effect on mental state
- Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death
- Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study
- Anti-Stress, Behavioural and Magnetoencephalography Effects of an l-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial
- L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety
- l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways
- A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood
- Hypolipidemic activity of Tamarix articulata Vahl. in diabetic rats
- Identification of oral cavity biofilm forming bacteria and determination of their growth inhibition by Acacia arabica, Tamarix aphylla L. and Melia azedarach L. medicinal plants
- The Role of Tamarix gallica Leaves Extract in Liver Injury Induced by Rifampicin Plus Isoniazid in Sprague Dawley Rats
- Chemical composition, antioxidant and antibacterial activities of Tamarix balansae J. Gay aerial parts
- Tamarix gallica phenolics protect IEC-6 cells against H2O2 induced stress by restricting oxidative injuries and MAPKs signaling pathways
- Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer’s and Type 2 Diabetes Diseases
- Potent antihyperglycemic and hypoglycemic effect of Tamarix articulata Vahl. in normal and streptozotocin-induced diabetic rats
- Evaluation of Antioxidant, Anticholinesterase, and Antidiabetic Potential of Dry Leaves and Stems in Tamarix aphylla Growing Wild in Tunisia
- Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues
- Livestrong.com List of Foods With Flavinoids
- Ginkgo Biloba for Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Ginseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity: A Randomised Trial
- Effects of Ginkgo biloba on dementia: An overview of systemic reviews
- Efficacy of Ginkgo biloba extract EGb 761 in dementia with behavioral and psychological symptoms: A systemic review
- Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B
- Efficacy and Safety of Ginkgo Biloba Pills for Coronary Heart Disease with Impaired Glucose Regulation: Study Protocol for a Series of N-of-1 Randomized, Double-Blind, Placebo-Controlled Trials
- Effects of standardized Ginkgo biloba extract on the acquisition, retrieval and extinction of conditioned suppression: Evidence that short-term memory and long-term memory are differentially modulated
- Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats
- Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials